Young Sik Cho Selected Research

(2- fluorobenzyl)- (2- methyl- 2- phenyl- 2H- chromen- 6- yl- amine)

1/2011

Discovery of (2-fluoro-benzyl)-(2-methyl-2-phenethyl-2H-chromen-6-yl)-amine (KRH-102140) as an orally active 5-lipoxygenase inhibitor with activity in murine inflammation models.

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Young Sik Cho Research Topics

Disease

10	Neoplasms (Cancer) 01/2021 - 08/2008
6	Squamous Cell Carcinoma of Head and Neck 01/2019 - 08/2014
6	Inflammation (Inflammations) 06/2017 - 08/2008
4	Asthma (Bronchial Asthma) 01/2015 - 08/2008
4	Necrosis 06/2014 - 06/2009
3	Edema (Dropsy) 01/2015 - 01/2010
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2014 - 09/2009
3	Atopic Dermatitis (Atopic Eczema) 06/2011 - 01/2010
2	Arthritis (Polyarthritis) 06/2017 - 06/2010
2	Mouth Neoplasms (Oral Cancer) 04/2016 - 07/2015
2	Rheumatoid Arthritis 01/2015 - 07/2012
2	Type 2 Diabetes Mellitus (MODY) 02/2014 - 05/2012
2	Leukemia 01/2011 - 01/2010
1	Stomach Neoplasms (Stomach Cancer) 01/2021
1	Carcinoma (Carcinomatosis) 01/2021
1	Neoplasm Metastasis (Metastasis) 04/2016
1	Malignant Mesothelioma 03/2015
1	Infections 06/2014
1	Ischemia 06/2014
1	Insulin Resistance 04/2014
1	Hyperplasia 12/2010
1	Metabolic Diseases (Metabolic Disease) 08/2010
1	Chronic Obstructive Pulmonary Disease (COPD) 02/2010
1	Skin Diseases (Skin Disease) 01/2010
1	Virus Diseases (Viral Diseases) 06/2009
1	Stroke (Strokes) 01/2009
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2009
1	Respiratory Hypersensitivity 08/2008
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 05/2002

Drug/Important Bio-Agent (IBA)

6	Pharmaceutical PreparationsIBA 01/2021 - 10/2013
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 10/2013
4	CaspasesIBA 08/2017 - 06/2009
3	EnzymesIBA 01/2015 - 07/2012
3	Arachidonic Acid (Vitamin F)IBA 01/2015 - 01/2010
3	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2015 - 01/2010
3	GlucocorticoidsIBA 04/2014 - 09/2009
3	Dinitrochlorobenzene (DNCB)IBA 06/2011 - 01/2010
2	Phosphotransferases (Kinase)IBA 01/2019 - 06/2009
2	licochalcone AIBA 03/2015 - 08/2014
2	Biological ProductsIBA 01/2015 - 02/2010
2	LeukotrienesIBA 01/2015 - 07/2012
2	11-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase)IBA 04/2014 - 09/2009
2	Fatty Acids (Saturated Fatty Acids)IBA 02/2014 - 05/2012
2	Leukotriene B4IBA 01/2011 - 01/2010
1	Fluorouracil (Carac)FDA LinkGeneric 01/2021
1	Celecoxib (Celebrex)FDA Link 01/2021
1	Janus KinasesIBA 01/2019
1	DAPIIBA 01/2019
1	licochalcone HIBA 01/2019
1	licochalcone DIBA 01/2019
1	AgarIBA 01/2019
1	licochalcone CIBA 12/2018
1	Protein Kinases (Protein Kinase)IBA 11/2018
1	Hydrocortisone (Cortisol)FDA LinkGeneric 06/2017
1	licochalcone BIBA 04/2016
1	AntioxidantsIBA 04/2016
1	manumycinIBA 11/2015
1	4-O-methylhonokiolIBA 07/2015
1	Sp1 Transcription FactorIBA 07/2015
1	Oxidoreductases (Dehydrogenase)IBA 04/2014
1	Cortisone FDA Link 04/2014
1	honokiolIBA 10/2013
1	ThiazolesIBA 07/2012
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 05/2012
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 06/2011
1	Immunoglobulin E (IgE)IBA 06/2011
1	cobamamide (adenosylcobalamin)IBA 06/2011
1	HydrogelsIBA 06/2011
1	(2- fluorobenzyl)- (2- methyl- 2- phenyl- 2H- chromen- 6- yl- amine)IBA 01/2011
1	Lipoxygenase InhibitorsIBA 01/2011
1	Peroxidase (Myeloperoxidase)IBA 01/2011
1	RoflumilastIBA 12/2010
1	Phosphodiesterase 4 InhibitorsIBA 12/2010
1	IsoenzymesIBA 08/2010
1	11-beta-Hydroxysteroid Dehydrogenase Type 1IBA 08/2010
1	CollagenIBA 06/2010
1	PyrimidinesIBA 02/2010
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 02/2010
1	4- (4- (4- fluorophenyl)thiazol- 2- ylamino)- 2,6- dimethylphenolIBA 01/2010
1	NF-kappa B (NF-kB)IBA 06/2009
1	Transcription Factors (Transcription Factor)IBA 06/2009
1	Glycogen Synthase Kinase 3 betaIBA 01/2009
1	prolinedithiocarbamate (PDTC)IBA 08/2008
1	OvalbuminIBA 08/2008
1	CytokinesIBA 08/2008
1	pyrrolidine dithiocarbamic acidIBA 08/2008
1	Nucleic AcidsIBA 05/2002

Therapy/Procedure

3	Therapeutics 08/2017 - 06/2011
2	Drug Therapy (Chemotherapy) 05/2018 - 05/2014
1	Radiotherapy 05/2014
1	Topical Administration 06/2011
1	Oral Administration 01/2011